42 results
Beta-Blockers in Cirrhosis
 • Pathophysiology
 • Indications:  Prevention of decompensation, Prevention of first variceal bleeding,
Beta-Blockers in Cirrhosis ... gastropathy • Dosing ... #hepatology #management ... #pharmacology # ... indications #dosing
Direct-acting oral anticoagulants (DOACs) for VTE treatment and prevention - Comparison Table

#DOAC #Anticoagulants #Anticoagulation #VTE #Management
anticoagulants (DOACs ... ) for VTE treatment ... and prevention ... Comparison Table #DOAC ... VTE #Management #Pharmacology
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
anticoagulant dosing ... Clotmaster #VTE #DOAC ... #Bridging #Dosing ... #Loading #DVT #Pharmacology ... #Hematology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Renal Dosing ... @Bloodman #DOAC ... Anticoagulation #Hematology ... #Pharmacology #
Preventing Decompensation in Cirrhosis 

cACLD, CSPH, and the Rule of Five
Prevention of Decompensation
Nonselective Beta Blockers (NSBB)
Preventing
Preventing Decompensation ... in Cirrhosis ... Decompensation #Cirrhosis ... #Prevention #treatment ... #management #hepatology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... anticoagulants (DOACs ... for appropriate dosing ... filtration rate; DOAC ... Anticoagulation #Management #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... DOACs are substrates ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... clearance (calculated using ... interruption per treatment ... Perioperative #Management #Treatment ... #pharmacology #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... those with CLD (± cirrhosis ... months without treatment ... #Failure #Cirrhosis ... #Hepatology #gastroenterology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology