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management diagnosis infections prevention idsa opportunistic hematology medications table disease syndrome differential neurology oncology gout comparison algorithm cardiology doac drugs
Coagulation Cascade and Anticoagulant Sites of Action - Amy Chung, MD, MSc https://twitter.com/AmyChung #AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Medications #Pharmacology ... #Pathophysiology ... Mechanisms #DOAC #Hematology
Role of Uric Acid in the Inflammation of Gout Allopurinol, Febuxostat - Xanthine oxidase Colchicine - Release of
gout #uricacid #pathophysiology ... #pharmacology # ... rheumatology
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... the first-line treatments ... #Pharmacology #Pathophysiology
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 TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... : 33% • Treatment ... transfusion • Pathophysiology ... : No • Treatment ... Transfusion #Reactions #hematology
Treatment of Wilson's Disease • D-penicillamine - Chelator, induces cupruria • Trientine - Chelator, induces cupruria
Treatment of Wilson's ... Aims to reduce level ... Wilsons #Disease #Treatment ... #management #pharmacology
Migraine - Preventative Treatments • Anticonvulsants: *Topiramate, *Sodium valproate, Gabapentin, Pregabalin • Antidepressants: Amitriptyline, Venlafaxine, Duloxetine,
- Preventative Treatments ... Cyproheptadine * Level ... #Preventative #Treatment ... prophylaxis #prevention #pharmacology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
- Nonremitting fever ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... , ↓ Fibrinogen level ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - 80% have fever ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. For lithium, target
vary depending on treatment ... mortality at a higher level ... Ranges #Toxicology #Pharmacology
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