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hematology algorithm secondary oncology pruritus enlarged eosinophilia mds myelodysplasia myelodysplastic nonpalpable palpable platelets purpura spleen splenomegaly syndromes
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis ... Polycythemia Vera • Primary ... Chronic Myeloid Leukemia ... Diagnosis #causes ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... • Primary Myelofibrosis ... following EtOH induced thrombocytopenia ... #Causes #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis ... and Primary Causes ... == Primary Skin ... Skin Lesion / Systemic ... #generalized #dermatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Post-splenectomy Primary ... Chronic myeloid leukemia ... Diagnosis #Causes ... #hematology #secondary
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... • Lymphoma • Leukemia ... vera, essential thrombocytosis ... Inflammatory • Systemic ... #Causes #Hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential ... Diagnosis Bugs: ... Lymphomas - Systemic ... #Diagnosis #Causes ... #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... • Lymphoma • Leukemia ... #generalized #dermatology ... #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
basophilia, and thrombocytosis ... + distinctive primary ... CLL -> Invade Skin ... #Hematology #Oncology ... #Diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... /Quantity: • Primary ... Causes: - Thrombocytopenia ... #Diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... • Hairy Cell Leukemia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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