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diagnosis oncology algorithm amiodarone cancer differential differentiation encephalopathy hemeonc hemophagocytic hlh immune induced inflammatory iris lacticacidosis leukostasis lung lymphohistiocytosis lysis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... #management #hematology
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... also includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis ... #Management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... compounds, alcohol, lead ... progression to AML ... #diagnosis #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Etiology: • Pathophysiology ... Neurological symptoms ... Medication/Drug toxicity ... #diagnosis #management
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
respiratory distress syndrome ... gradually with symptoms ... Improvement in symptoms ... Pulmonary #diagnosis #management ... #Toxicology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... • ART ↓ viral load ... Drug reaction/ART toxicity ... #Inflammatory #Syndrome ... Differential #Diagnosis #Management
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... Myelodysplastic syndromes ... disease-associated symptoms ... risk of organ toxicity ... #algorithm #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
TAFRO TAFRO syndrome ... cell lymphoma Pathophysiology ... and the systemic symptoms ... TAFRO #diagnosis #management ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Common Signs and Symptoms ... Pathophysiology ... #Hematology #HemeOnc
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