40 results
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... determine response to diuretic ... #hyperkalemia ... #diuresis #nephrology ... #algorithm
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... urearetics) 3) Loop ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... anhydrase inhibitors, loop ... syndrome (mimics loop ... or induced) #Hypokalemia ... differential #diagnosis #nephrology
Mechanism of Action of Diuretics
Amiloride, Triamterene, Spironolactone
Loop Diuretics
Thiazides
Acetazolamide

#Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Mechanism of Action of Diuretics ... Spironolactone Loop ... Diuretics Thiazides ... #pharmacology #pathophysiology ... #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... Clinicians should also look ... Post-hypercapnia • Diuretics ... differential #diagnosis #algorithm ... #causes #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop ... #Pharmacology #nephrology ... #conversion #loop
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... mannitol) 3) Loop ... Diuretics (e.g. ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... • HTN Absent: Loop ... and thiazide diuretics ... potassium #low #nephrology
Continuous Renal Replacement Therapy (CRRT) - Overview
Types of CRRT
 • CVVHD - Continuous Veno-Venous hemodialysis -
Hemofiltration - Convection ... - Diffusion + convection ... electrolytes (essentially hyperkalemia ... volume overload; diuretic ... #Indications #Nephrology
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... renal function) - Loop ... diuretic (often ... LouLectures #Hyperkalemia ... management #potassium #nephrology