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management hematology hemophagocytic lymphohistiocytosis physicalexam hemeonc lupus neurology syndrome anisocoria chest comparison druginduced empyema en erythematosus frenzy heparin hit horners
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... Autoimmune diseases: SLE ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... Splenomegaly • Low ... • Bicytopenia Treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... erythematosus [SLE ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... in >90% - Low ... #comparison #table ... #rheumatology # ... diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... by uncontrolled activation ... Clinical Presentation ... Low/absent NK-cell ... #Management #Hematology
Empyema Necessitans (EN) on Chest Wall Physical Examination Pulmonary teaching case: you are called to the bedside
he coughed and now ... drain - What’s the diagnosis ... Fusobacterium Treatment ... #PhysicalExam #clinical ... #video #pulmonary
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 SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... anti-Smith Ab, low ... , lymphopenia, low ... Chronic B-cell activation ... #Rheumatology
Horner's Syndrome on Physical Exam A 75yoF was referred in for facial swelling and eyelid changes 1
consistent with a diagnosis ... or induced by treatment ... how the right pupil ... Horners #Syndrome #clinical ... #physicalexam #neurology
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 Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
complex → plt activation ... Confirmatory test ↑Se ... /Sp but very slow ... #Management #Treatment ... #Hematology #HemeOnc
Propofol Frenzy on Neurological Examination Propofol frenzy; Presented with a cluster of seizures, now on Propofol, being
Diagnosed as Propofol ... [idiosyncratic SE ... NMDA receptor activation ... Propofol #Frenzy #clinical ... #video #neurology
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