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management algorithm dermatology pruritus systemic anemia cd4 chronic cll eosinophilia eosinophils hes hypereosinophilia icl idiopathic lymphocytopenia lymphopenia mds myelodysplasia primary
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Cancer affecting lymphocytes ... cell neoplasm • Lymphocytes ... Absolute blood lymphocyte ... #Leukemia #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
): • Lymphocytes ... CLL (Chronic Lymphocytic ... Leukemia): • Lymphocytes ... and/or Small Lymphocytic ... #Hematology #Oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis ... Liver Function Tests ... • Lymphoma • Leukemia ... syndrome Psychiatric ... #dermatology #Differential
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Liver Function Tests ... • Lymphoma • Leukemia ... syndrome Psychiatric ... #dermatology #Differential ... #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... • Aplastic Anemia ... blood count with differential ... #Syndromes #diagnosis ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anemia Clinical ... and petechiae Causes ... virus (EBV) • Leukemia ... #Anemia #oncology ... #hematology #diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
underlying primary or secondary ... mL or 20% total lymphocyte ... Heme (lymphoma. aplasia ... /myelodysplasia) ... #hematology #Differential
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
than 1500 and clinical ... blood eosinophilia Secondary ... Causes: - Allergic ... Myeloproliferative HES - Lymphocytic ... #hematology #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... other diseases • Secondary ... salivary ducts Clinical ... UIP, NSIP): • Lymphocytic ... phenomenon (16%) MSK
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