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diagnosis hepatology differential algorithm causes liver primary signs sjogrens syndrome cholangitis hepatitis hepatomegaly injury lfts liverenzymes management pathophysiology pbc rheumatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... congenital - Primary biliary ... cirrhosis - α1 ... - Wilson disease ... Venoocclusive disease
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 Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
for Liver and Biliary ... Kayser-Fleischer rings in Wilson's ... Bruising, Edema #biliary ... #physicalexam # ... cirrhosis #liver
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Autoimmune • Wilson's ... • Drugs • Wilson's ... • Cholestatic disease ... Infiltrative • Cirrhosis ... Duct Stone • Biliary
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... Pathophysiology: • T lymphocyte ... cholestasis → Cirrhosis ... #Cirrhosis #PBC
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... processes like primary biliary ... cirrhosis (PBC) ... with systemic diseases ... Symptoms: - Lymphocyte
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Metabolic/Hereditary: Wilson ... Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... hepatitis: < 1 • Cirrhosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... glands: • Focal lymphocytic ... UIP, NSIP): • Lymphocytic ... hepatitis, primary biliary ... cirrhosis: 3%-20%
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