11 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Ischemia, AIH, Wilsons ... AIH, A1AT def, Wilson's ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Cholestatic disease ... Infiltrative • Cirrhosis ... • Others #LFTs ... #LiverEnzymes #Differential
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... Primary biliary cirrhosis ... - Wilson disease ... Venoocclusive disease ... #Diagnosis #Differential
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Liver and Biliary Diseases ... Kayser-Fleischer rings in Wilson's ... disease 3) Chest ... Edema #biliary #physicalexam ... #cirrhosis #liver
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Primary Biliary Cirrhosis ... #Hepatomegaly #Differential
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Liver Injury - Differential ... Hemochromatosis, Wilson's ... disease, Alpha- ... HELLP, Celiac disease ... Transaminitis #LFTs
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Medications • Wilson's ... disease • Silver ... discoloration) • Liver cirrhosis ... #dermatology #Differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... Pathophysiology: • T lymphocyte ... cholestasis → Cirrhosis ... but elevated as disease ... bile ducts Differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... of cholestatic disease ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Metabolic/Hereditary: Wilson ... , Celiac disease ... hepatitis: < 1 • Cirrhosis ... injury #hepatitis #differential