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diagnosis hepatology algorithm causes hematology liver lfts anemia biliary hemolysis injury primary signs transaminitis workup abnormal acute cd4 chemistry cholangitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Ischemia, AIH, Wilsons ... AIH, A1AT def, Wilson's ... Ducts - PBC ... Congenital, Others, Cirrhosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... • Cholestatic disease ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... #LiverEnzymes #Differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... Pathophysiology: • T lymphocyte ... cholestasis → Cirrhosis ... but elevated as disease ... bile ducts Differential
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... Primary biliary cirrhosis ... - Wilson disease ... Venoocclusive disease ... #Diagnosis #Differential
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 Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Metabolic/Hereditary: Wilson ... Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... hepatitis: < 1 • Cirrhosis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Hemochromatosis, Wilson's ... Disease, Alpha- ... Malignancy, 1° PBC ... Liver #Injury #Differential
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Liver and Biliary Diseases ... Kayser-Fleischer rings in Wilson's ... disease 3) Chest ... Edema #biliary #physicalexam ... #cirrhosis #liver
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Primary Biliary Cirrhosis ... #Hepatomegaly #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Drugs, Liver Disease ... Electrolytes: Wilson's ... disease, Hypophostphatemia ... #Hemolysis #Differential
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Medications • Wilson's ... disease • Silver ... discoloration) • Liver cirrhosis ... #dermatology #Differential
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