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diagnosis hepatology differential algorithm causes biliary liver ah aih antigen autoimmune carcinoembryonic cea cholangitis criteria hepatomegaly injury laboratory lfts liverenzymes
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... • Onset of jaundice ... metabolic liver disease ... (Wilson disease ... #Hepatitis #AH
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Sarcoidosis Toxic - Alcohol ... - Wilson disease
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 Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• NAFLD • Alcohol ... • Cholestatic disease ... Ducts • PSC • Alcoholic ... hepatitis • Drugs ... Infiltrative • Cirrhosis
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... Kayser-Fleischer rings in Wilson's ... Edema #biliary #physicalexam ... #cirrhosis #liver
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Inflammatory • Alcoholic ... Induced Hepatitis ... Primary Biliary Cirrhosis
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... or 60 (male) g alcohol ... metabolic liver disease ... (Wilson disease
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... Pathophysiology: • T lymphocyte ... cholestasis → Cirrhosis ... hyperpigmentation • Jaundice ... Diagnosis: • Viral hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Metabolic/Hereditary: Wilson ... ALT Ratios: • Alcoholic ... Chronic viral hepatitis ... : < 1 • Cirrhosis ... liver #injury #hepatitis
Carcinoembryonic antigen (CEA) • CEA is a highly glycosylated cell surface glycoprotein involved in intercellular adhesion
Rectal polyps, Hepatitis ... , Alcoholic cirrhosis ... , Obstructive jaundice ... Smokers, Renal disease
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