12 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic hepatitis ... - Autoimmune ... hepatitis - Wilson ... disease - Hemochromatosis ... #Differential #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... Hepatitis - Onset ... (Wilson disease ... SMA >1:80 #Autoimmune ... #Hepatology #AIH
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Schistosomiasis - Autoimmune ... - Wilson disease ... #Differential #Hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... • Autoimmune ... Hepatitis • Drug ... Algorithm #Causes #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... ) • Onset of jaundice ... metabolic liver disease ... (Wilson disease ... #AH #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... • Wilson's ... • Cholestatic disease ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
• Metabolic: Wilson ... Disease • Vascular ... obstruction syndrome • Autoimmune ... hepatitis • Iatrogenic ... Diagnosis #causes #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's ... Disease, Alpha- ... Other: NAFLD, Autoimmune ... Syndrome, Celiac Disease ... Acute #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... Hemochromatosis, Wilson's ... disease, Alpha- ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology: • T lymphocyte ... hyperpigmentation • Jaundice ... but elevated as disease ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology