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Jaundice and Kayser-Fleischer Rings in Wilson's Disease

#Jaundice #Kayser #Fleischer #Rings #Wilsons #Disease #clinical #video #ocular #physicalexam
Jaundice and Kayser-Fleischer ... Rings in Wilson's ... Disease #Jaundice ... #Disease #clinical ... video #ocular #physicalexam
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
for Liver and Biliary ... erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... Kayser-Fleischer rings in Wilson's ... #physicalexam #
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic hepatitis ... - Acute biliary ... - Autoimmune hepatitis ... - Wilson disease ... Hemochromatosis - Primary biliary
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... congenital - Primary biliary ... - Wilson disease ... Venoocclusive disease
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... Cholangitis • Primary Biliary
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's ... Disease, Alpha- ... , Acute biliary ... Syndrome, Celiac Disease ... Extrahepatic • Biliary
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... ) • Onset of jaundice ... before the onset of jaundice ... metabolic liver disease ... (Wilson disease
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... before the onset of jaundice ... metabolic liver disease ... (Wilson disease
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Autoimmune • Wilson's ... • Drugs • Wilson's ... • Cholestatic disease ... • Alcoholic hepatitis ... Duct Stone • Biliary
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology: • T lymphocyte ... hyperpigmentation • Jaundice ... but elevated as disease ... Diagnosis: • Viral hepatitis