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diagnosis leukemia chronic hemeonc rheumatology classification cvid differentiation hemophagocytic hlh hodgkins hypogammaglobulinemia immunodeficiency immunology lymphohistiocytosis lymphoma mds myelodysplasia myelodysplastic polychondritis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... -> AML: Blast crises ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... immunophenotype Clinical ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... • Induce blast cell ... #management #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Most common cytopenia ... progression to AML ... #diagnosis #hematology ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... Granulomatous lymphocytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Hodgkin Lymphoma - Clinical ... (NSHL) - (most common ... classification #hematology ... #oncology #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... UIP, NSIP): • Lymphocytic ... Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Acquired) HLH: - Common ... Clinical Presentation ... • Common Signs ... #Hematology #HemeOnc
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... chondritis is the most common ... clinical manifestation ... SLE • RA - Most common ... #diagnosis #management
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