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diagnosis hematology management differential rheumatology activation bruising cardiology causes chronic cll common cryofibrinogenemia cvid hemeonc hemophagocytic history hlh hypogammaglobulinemia immunodeficiency
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered ... Vascular System ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... cells can indicate disease ... ’s CLL Scoring system ... lymphoproliferative disorders ... • Richter’s Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... IL-1 and IL-6, leading ... purpura to mucosal bleeding ... Histopathologic criteria ... Diagnosis #Management #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Granulomatous lymphocytic ... hemolytic anemia) • Systemic ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
von Willebrand disease ... • Presence of systemic ... von Willebrand disease ... Marfan syndrome, ... #Bleeding #Disorders
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... cryoglobulinemia Associated Disorders ... processes: • Systemic ... Antiphospholipid syndrome ... #rheumatology #hematology
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
(sick sinus syndrome ... Anticholinergics Systemic ... Hyperthyroidism • Anemia Psychiatric ... : • Panic disorder ... straight after bending
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... ▪ Autoimmune diseases ... Diagnostic Criteria ... of 8 HLH-2004 criteria ... malignancy, autoimmune disorder
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