19 results
Muddy Brown Granular Casts three ways - Brightfield, Darkfield, Phase Contrast.

Dr. Vipin Varghese @vipvargh

#Muddy #Brown #Granular
Muddy Brown Granular ... #Muddy #Brown #Granular ... urine #microscopy #MBGC
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
LDH Peripheral smear ... Laboratory #Testing #workup
Neoplastic plasma cells with nucleoli (left image) and intranuclear Dutcher body (right image).

Dutcher bodies are round,
bodies are round, agranular ... appear somewhat granular ... Pathology #Clinical #Smear
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... Hematology #Clinical #Smear
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
of crystallized granules ... BloodSmear #Blood #Smear
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
/uL Initial Workup ... acid, peripheral smear ... Algorithm #hematology #workup
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
abundant cytoplasmic granules ... peripheral blood smear ... decreased secondary granules ... BloodSmear #Blood #Smear
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Large platelets on smear ... platelet clumping on smear ... Large platelets on smear ... of platelet α-granules ... colored platelets on smear
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... Thick and thin smear ... UnknownOrigin #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... peripheral blood smear ... dysplasia on the smear ... Diagnosis #Causes #Workup