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diagnosis management cardiology rheumatology endocarditis lymphoma treatment algorithm antibodies associations autoantibodies cardiomyopathy chronic classification comparison disorders erythematosus fever fuo hemophagocytic
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Other hematologic ... CML, ALL) • Solid ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
syndrome Anti-Scl ... - Vasculitis, e.g ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
classical HL (MCHL ... Immunohistochemical studies (to differentiate ... number of sites of disease ... classification #hematology ... #oncology #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... function test, ANA (e.g ... ., SLE), anti-phospholipid ... changes), high MCV ... not required in all
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
Causes of Fever ... Neoplasm: • NHL • Hodgkin's ... Autoimmune: • SLE ... Tuleremia • Septic ... • Protozoa (eg
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... extramedullary disease ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
+++ (Plt, Hb), Hepatic ... Hemopathies+++: Hodgkin ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease,
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... vein thrombosis Hematologic ... La, anti-Jo-1, SCL ... cyclophosphamide) • Hodgkin
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Autoimmune (SLE ... Glomerulonephritis Septic ... Emboli Cause Injury ... Marantic (NTBE) Differential ... ↑ ESR, CRP • EKG
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Differential Diagnosis ... Valvular heart disease ... orthopnea, PND, LE ... during Delivery • Stable
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