11 results
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
malignancy Pathophysiology ... Differential Diagnosis ... levels to <1ng/mL ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... ) from the pituitary ... #Acromegaly #Signs ... Symptoms #Diagnosis #Endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... - Giantism or acromegaly ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... rare causes of acromegaly ... signs #symptoms #endocrinology ... #pathophysiology
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Sellar / Pituitary ... Mass - Differential ... Prolactin • GH ... #Differential # ... Diagnosis #Algorithm #endocrinology
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
syndrome • Various Pituitary ... path • Acromegaly ... MultipleEndocrineNeoplasia #Differential ... #Endocrinology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Growth Hormone (GH ... MRI to evaluate pituitary ... evaluation of other pituitary ... Algorithm #diagnosis #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... following order; GH ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Tall Stature - Differential ... Puberty Onset • GH ... Resistance • Acromegaly ... #TallStature #Differential ... Diagnosis #Algorithm #endocrinology
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework

Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
Hypothyroidism - Differential ... ↓FT4 • Post-GH ... drug-induced • Pituitary ... Hypothyroidism #Differential ... Diagnosis #algorithm #endocrinology