35 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PT, aPTT(liver disease ... (CVID, WAS), (neurologic ... changes), high MCV ... not required in all ... #Workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... lupus cases, drug-dependent ... NPSLE rare, Malar rash ... Manifestations: Malar rash ... Evolution: Chronic disease
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Manifestations: Malar rash ... Positive in 60-80% of cases ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
RED FLAGS - In all ... cases there are ... suspicion of severe disease ... splenomegaly, abnormal neurology ... , back pain Haematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... Venoocclusive disease ... Hereditary: Wilson Disease ... : > 2 • NASH, ... diagnosis #algorithm #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Systemic lupus ... Petechial or purpuric rash ... tests ↑ AST ↑ ALT ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
contagious of all ... with or without treatment ... , but without treatment ... resembling rashes caused ... Clinical #Photo #Dermatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... but elevated as disease ... obstruction • ALP ... diagnosis #workup #hepatology