9 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PT, aPTT(liver disease ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... changes), high MCV ... #Workup #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Systemic lupus ... Petechial or purpuric rash ... erythematosus [SLE ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... : SLE+++, Adult-onset ... Still disease, ... Treatment: • ... #summary #rheumatology
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
and Management Summary ... rule out other causes ... of neurologic/cognitive ... over course of disease ... #hepatology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
and Management Summary ... Prevalence: 1-2 cases ... Person Syndrome Pathophysiology ... Person Syndrome Treatment ... #neurology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... cell lymphoma Pathophysiology ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology