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management photo rheumatology hemophagocytic lymphohistiocytosis differential algorithm dermatomyositis treatment activation antimda5 antinxp2 antinxp2dm bandemia blood canimorsus capnocytophaga cbc classification criteria
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
) Clinical Features ... : ↑↑ ferritin, Anemia ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... #hematology #criteria
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... dorsal part of the MCP ... auricular papules Clinical ... dermatology #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... Petechial or purpuric rash ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... sIL-2R >2400 Ul/ml ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Presentation / Diagnosis ... Diagnosis via genetic ... Ferritin >500 ng/mL ... management #treatment #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
and Differential Diagnosis ... CD13, CD33, CD34, HLA-DR ... Pelger-Huet, Macrocytic anemia ... CD23, o CML ... Blood #Disorders #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immune hemolytic anemia ... (MCHL) - Lymphocyte ... classification #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Differential Diagnosis ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Canimorsus Skin Rash ... Bandemia, AKI. ... possible Patient's clinical ... the key to the diagnosis ... #dermatology #clinical
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
General Approach to Anemia ... - Differential Diagnosis ... haptoglobin) 3) Use MCV ... & clinical context ... #hematology #algorithm
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