11 results
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... poisoning Normal acid-base ... and potassium acid ... urine #Algorithm #nephrology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Algorithm - Urinary Chloride ... suction, Congenital chloride ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... poisoning • Normal acid-base
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Metabolic alkalosis ... • Fatigue Chloride ... secretion • Acid-base ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... Hypokalemia Metabolic alkalosis ... #Pathophysiology ... #nephrology #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Cystinuria - Amino acid ... limb Gitelman syndrome ... tubule Liddle syndrome ... Defects #Kidney #Nephrology ... #Differential #Table
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Acid Base Disorders ... (AG) = {Na - (Cl ... D-lactate (short bowel syndrome ... Diagnosis #Summary #Nephrology ... ABG #bloodgas #Acid
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... • Congenital chloride ... #diagnosis #nephrology ... #management #pathophysiology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic Alkalosis ... Fractional excretion of Cl ... dr_missyhanna #Gitelman #Syndrome ... #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
• Metabolic alkalosis ... Inhibitors of Na+K+2Cl ... Bumetanide, Ethacrynic acid ... Excretion #Diuresis #Nephrology ... #Medications #Table
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Stiff Person Syndrome ... Pathophysiology ... Anti-GAD Ab (>1000u/ml ... antibody that works ... Management #treatment #neurology