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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis ... #causes
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... Diagnosis Secondary ... Myelodysplastic syndrome ... myeloid leukemia (CML ... #Diagnosis #Causes
Common Raynaud's Mimickers
 - Acrocyanosis
 - Chill blains (pernio)
 - Erythromelalgia
 - Frostbite
 - Achenbach's Syndrome

Dr.
- Achenbach's Syndrome ... Raynauds #mimickers #Differential ... #Diagnosis #Causes ... #Mimics #rheumatology
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

 -
Raynaud Phenomenon Differential ... Diagnosis: Rheumatologic ... - MCC systemic ... - Frostbite #Diagnosis ... #Differential
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Diagnosis Platelet ... Non-infectious (malignancy, rheumatologic ... Thrombocytosis #Differential ... #Diagnosis #causes
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... Myelodysplastic syndrome ... #differential # ... diagnosis #causes ... #hematology
Differential Algorithm for the Causes of thrombocytopenia 

#Diagnosis #Hematology #Thrombocytopenia #Causes #Differential
Differential Algorithm ... for the Causes ... thrombocytopenia #Diagnosis ... #Hematology #Thrombocytopenia ... #Causes #Differential
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... Sarcoidosis or Lofgren's syndrome ... #Differential # ... Diagnosis #Dermatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... ) - Differential ... Diagnosis Algorithm ... #Diagnosis #Algorithm ... #Causes #Hematology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... Diagnosis Algorithm ... Metabolic #Alkalosis #Differential ... #Diagnosis #Algorithm ... #Nephrology #Causes