30 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Syndrome: Distal ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
NGT suction, Low Cl ... • High Urine Cl ... , Gitelman Syndrome ... , Liddle syndrome ... Diagnosis #Algorithm #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... syndrome - Thiazide-sensitive ... tubule Liddle syndrome ... Defects #Kidney #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
NGT suction, Low Cl ... • High Urine Cl ... , Gitelman Syndrome ... , Liddle syndrome ... Diagnosis #Algorithm #Nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
acid, Liddle's Syndrome ... Normotensive: • UCl ... Post-hypercapnia • UCl ... , Gitelman's syndrome ... Diagnosis #Algorithm #nephrology
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
Gitelman Syndrome ... - Management Treatment ... Mg, preferably Cl ... #Syndrome #Management ... #Treatment #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
of hypokalemia starts ... , Gitelman's syndrome ... acid, Liddle's syndrome ... • Cushing's syndrome ... algorithm #causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... Hypocalciuria (spot ... #nephrology #management ... #pathophysiology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
excess, Liddle syndrome ... • Low Urine Cl ... • High Urine Cl ... , Gitelman syndrome ... algorithm #diagnosis #nephrology