11 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... CD23, o CML ... Thrombocytosis (ET ... #hematology #Markers ... #Algorithm
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Rare inflammatory disorder ... : High spiking fever ... Disease #AOSD #rheumatology ... #treatment
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Ferritin >3000 ng/mL ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology #
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
hemoproliferative disorder ... PV, MDS, CML) Treatment ... • Treatment algorithms ... #hematology #diagnosis ... #management #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Adult-onset Still ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... +, Adult-onset Still ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
respiratory symptoms • Fever ... , cough, chills, ... symptoms • Rheumatologic ... infection • Cough, fever ... • Isolated fever
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Differential Diagnosis ... arthritis, adult-onset Still ... to: Arthritis, Fever ... #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... • Dyspnea • Fever ... classical HL (MCHL ... Hodgkin Lymphoma Treatment ... classification #hematology