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management hematology hemophagocytic lymphohistiocytosis pediatrics risk stratification syndrome activation adultonset antibiotics behcet brain cancer classification cop crypto cryptococcal cryptogenic evaluation
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... frequently affects infants ... age, however the disease ... following: • Fever ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... • Autoimmune diseases ... #summary #rheumatology
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... with fever without ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... is the main clinical ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... : Fever, Arthralgia ... Differential Diaqnoses ... hepatitis • Pulmonary ... #treatment #rheumatology
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
incomplete Kawasaki Disease ... Infants ≤6 months ... old on day ≥7 of fever ... echo is positive, treatment ... #Diagnosis #Peds
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... Onset: Usually in infancy ... ▪ Autoimmune diseases ... Clinical Presentation ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
common in Asia • HLA-B51 ... association • M > F Clinical ... Behcet syndrome (Clinical ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... symptoms • Rheumatologic ... has five major clinical ... fungal stain of clinical ... • Isolated fever
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... • Dyspnea • Fever ... (MCHL) - Lymphocyte ... number of sites of disease ... Hodgkin Lymphoma Treatment
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