32 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... Acute bacterial and ... #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and ... Autoimmune Diseases: • Systemic ... Differential #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
alveolitis, ear and ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... identified in 25 men ... Autoinflammatory #Somatic #rheumatology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Iron deficiency anemia ... Mellitus Half-and-Half ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Differential Diagnosis Neurologic-Centered ... : (+) Systemic ... capillary leak syndrome ... • Schnitzler syndrome ... Differential #Diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
clubbing Clarkson/Systemic ... et diutinum Neurologic ... neuropathy) • Systemic ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Differential Diagnosis Algorithm ... Myelodysplastic Syndromes ... • Rule out B12 and ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5. ... Acquired Aplastic Anemia ... marrow failure syndrome ... #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
severe disease and ... guidelines General - Systemic ... splenomegaly, abnormal neurology ... cell disease Rheumatology ... #Limping #NWB #Algorithm