15 results
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • MGCSMGRS ... capillary leak syndrome ... Hyperviscosity syndrome ... WAIHA • CAD • PCH
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Myeloma • MGUS ... • Fanconi's syndrome ... proliferative • Anti-GBM
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
C, A, E, B, D, EBV ... obstruction, HELLP Syndrome ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
biliary cirrhosis (PBC ... Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Celiac disease Anti-GBM ... Goodpasture's syndrome
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... Cold Agglutinin Syndrome ... - Mycoplasma, EBV ... significance (MGUS ... Hemoglobinuria (PCH
ISCHEMIA Trial - Management Algorithm for patients with Stable Angina

Stress Test -> ? +moderate or severe
revascularization (PCI ... acute coronary syndrome ... Algorithm #Cardiology #EBM
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
vein: Budd-chiari syndrome ... HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... • Gilbert's syndrome
Supracondylar Elbow Fracture
• Most common elbow fracture in children, peak age 5-7 
• When looking at
), compartment syndrome ... Posterior long arm • Ortho ... Type l, DC with ortho ... MH/CCF/CWRU EM
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
Demyelination Syndrome ... Dextrose in water @ 3cc ... MH/CCF/CWRU EM
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Diagnosis- Compatible syndrome ... toxo IgG • CNS PCR ... granulomatosis: • EBV-associated