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hematology monoclonal gammopathy anemia differential significance agglutinin ankle aplastic chronic cll cold complications disease gammopathies hemolytic impingement leukemia lymphocytic management
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... Renal-centered (ie "MGRS ... #Significance #MGUS ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... ) MGRS: • Fibrillar ... #Differential #Diagnosis ... #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... constitutional symptoms ... #diagnosis #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS ... hemolytic #anemia #hematology ... #diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... treatment of infective symptoms ... rituximab (in clinical ... high-risk situations #MGUS ... Complications #diagnosis
Posterior Ankle Impingement (Os Trigonum) Syndrome - MSK Radiology Imaging Findings: • Os trigonum which has marrow
(Os Trigonum) Syndrome ... - MSK Radiology ... flexion but no symptoms ... #clinical #Radiology ... #diagnosis #msk
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... • Richter’s Syndrome ... #workup #oncology ... #hematology
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