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hematology differential disease hemophagocytic lymphohistiocytosis neurology activation algorithm apml barre behcet calcium cardiology causes chf clinical cppd criticalcare deposition dermatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Unknown cause Treatment ... of emergency, ICU ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... • Bicytopenia Treatment ... agent are the main ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Fever is the main ... • HLH Labs: ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary ... severe disease Treatment ... Hydroxychloroquine *Short ... #diagnosis #rheumatology ... #management
Monteggia Fracture Fracture of proximal ulnar shaft with radial head dislocation. Remember “MUGR” to recall where
Here’s a quick summary ... ), compartment syndrome ... ligamentous injury (LCL ... : Pain control ... Radiology #XRay #Diagnosis
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
- Summary Acute ... • Weakness: Starts ... Hands or feet • Pain ... #diagnosis #management ... #treatment #neurology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... anterior chest wall, parts ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Framework and Management ... Summary Causes ... - Abdominal pain ... #Management #causes
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... effusions, weight gain ... organ dysfuxtion, ICU ... #management #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
common in Asia • HLA-B51 ... Arthritis, AS Treatment ... Nonsurgical abdominal pain ... #diagnosis #management ... signs #symptoms #rheumatology
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