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Intrinsic Renal Disease - Differential Diagnosis
Vascular:
 • Macrovascular: Renal artery occlusion, Fibromuscular disease
 • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... Glomerulonephritis #MPGN
Acanthocyte on Urine Microscopy

Not a spaceship, not a UFO, just an acanthocyte caught “flying” in dark
Acanthocyte on Urine Microscopy ... Urinary Sediment Microscopy ... presentation of RPGN ... Acanthocyte #Urine #Microscopy
Crusted Scabies - Physical examination now revealed a generalized erythematous and scaly rash with intense hyperkeratotic
Microscopic examination ... CrustedScabies #Scabies #Microscopy ... #NEJM
Excoriated papules with honey-colored crusting were present on the abdomen, back (Panel A), arms, and legs.
mite under light microscopy ... Pathology #Scabies #Microscopy ... #Rash #NEJM
Borrelia recurrentis Infection - Spirochetes were visible (arrows), a finding that suggested louseborne relapsing fever #Clinical
Recurrentis #Smear #Microscopy ... #NEJM
Auer Rods - Bone marrow aspiration revealed 5% blasts and 65% promyelocytes; many promyelocytes had prominent
AcutePromyelocyticLeukemia #Smear #Microscopy ... #NEJM
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... StanfordChiefs #RPGN
African Trypanosomiasis - The examination was notable for the two erythematous lesions, each measuring 3 to
Pathology #Smear #Microscopy ... TrypanosomaBrucei #NEJM
Urine Microscopy Instructions
1) Spin fresh urine sample (10-15mL) in a centrifuge for 3-5 minutes - Don't
Urine Microscopy ... one drop on a microscope ... iMedEducation #Urine #Microscopy