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Ascites Differential Diagnosis Table - Serum Ascites Albumin Gradient (SAAG)

SAAG ≥ 1.1:
 • Cirrhosis
 • Portal
SAAG ≥ 1.1: • Cirrhosis ... • Nephrotic syndrome ... • Malignancy ... #Serum #Albumin ... Gradient #SAAG #hepatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
according to the serum ... ascites albumin ... protein ≤ 2.5 g/dL: Cirrhosis ... SAAG #ascites #albumin ... #gradient #hepatology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
Indications for Albumin ... for Management ... of Cirrhosis • ... • Hepatorenal syndrome ... #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis
High albumin gradient (>1.1 g/dl):
 - Cirrhosis	
 - Alcoholic
Serum Ascites Albumin ... >1.1 g/dl): - Cirrhosis ... ascites without cirrhosis ... - Nephrotic syndrome ... Differential #Diagnosis #hepatology
Ascites - Diagnostic Approach and Differential Diagnosis
The most common causes: cirrhosis, malignancy and heart failure. Approx
common causes: cirrhosis ... one cause (e.g. cirrhosis ... differential, albumin ... perforation), Serum ... Differential #Diagnosis #hepatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
split products, albumin ... precipitate in serum ... Disorders: • Malignancy ... Antiphospholipid syndrome ... #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
LFTs R-value: Serum ... Production: • Albumin ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... #differential #Hepatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
primary biliary cirrhosis ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... and Arthritis Malignancy ... Diagnosis #Management
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... liver disease: cirrhosis ... Criteria): • ↑ Serum ... - IV albumin ... #Hepatology #Nephrology