22 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined ... #Neutropenia #Differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... #Diagnosis #Hematology
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... #Vitamins #Deficiency ... #differential # ... signs #symptoms #nutrition
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... loss), Vitamin B12 ... Production #Index #hematology ... #anemia #differential
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... may cause severe clinical ... hyperparathyroidism Treatment ... #Differential # ... Diagnosis #Pathophysiology
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... Check for IF ab Treatment ... #Cobalamin #Deficiency ... diagnosis #management #nutrition
Etiologies of Vitamin B12 Deficiency
 • Inadequate intake - Rare but seen in very strict vegans
Deficiency • Inadequate ... deficiency. ... #differential # ... diagnosis #hematology ... #nutrition
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
- Differential ... Framework and Clinical ... Manifestations #Differential ... syndromes #beriberi #nutrition ... #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... persons with poor nutrition ... Clinical Presentation ... vasculitis Treatment ... #Nutrition #Diagnosis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... fraction < 20% Differential ... mevalonate kinase deficiency ... diagnosis #management #treatment ... #rheumatology