Maturation deficiency hematology diagnosis rash purpura lupus alopecia systemic syndrome symptoms differential anemia antibodies erythematosus mas loss management

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Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin

(75%), Weight loss ... , Vasculitis, Purpura ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology

Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
• Scarring Alopecia:

Allopecia - Differential ... : Lupus erythematosus ... , Loose anagen syndrome ... #alopecia #Differential ... #Diagnosis #dermatology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... arthritis, weight loss ... Differential ... lupus erythematosus ... #Diagnosis #Rheumatology

Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

Systemic Lupus Erythematosus ... 69% - Malar rash ... - Hemolytic anemia ... Diagnosis and Lupus ... #Lupus #Erythematosus

Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of

lupus erythematosus ... rash) • Heart, ... lupus erythematosus ... with leukopenia, anemia ... #Diagnosis #Management

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

mucositis - Rash ... Diagnosis: Systemic ... systemic lupus ... Symptoms (Sx) in ... #diagnosis #rheumatology

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

Constitutional symptoms ... months to years) Systemic ... Lupus Erythematosus ... Photosensitivity, Alopecia ... #diagnosis #management

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

Diagnosis: • Systemic ... Symptoms (SX) in ... ischemia • Skin: Erythematous ... , mucositis • Rash ... #Diagnosis #Rheumatology

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