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diagnosis rheumatology dermatology lupus sle hemophagocytic hlh lymphohistiocytosis skinrash summary systemic adultonset antinxp2 antinxp2dm cutaneous dermatomyositis druginduced larva macrophage mas
Still's Disease: Characteristic rash seen in the adult form of this disease. Photo credit, Josh Fierer,
Still's Disease: ... Characteristic rash ... seen in the adult ... Photo credit, Josh ... #Photo #Dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... rheumatoid arthritis, adult-onset ... Malignancy (e.g. hematologic ... lymphoproliferative syndrome Clinical ... Chronic B-cell activation
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... arthritis, Skin rash ... #diagnosis #management ... #treatment #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Petechial or purpuric rash ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... Systemic Lupus Erythematosus ... Evolution: Chronic disease ... druginduced #lupus #sle #comparison
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... age, however the disease ... also observed in adults ... #treatment #hematology
Cutaneous larva migrans skin Rash 25 F recent Caribbean vacation, walked barefoot on sand and now with
Adult hookworms ... Diagnosis is clinical ... No treatment is ... rates of recurrent disease ... #clinical #photo
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
Viral zoonotic disease ... both children and adults ... three weeks Clinical ... Respiratory distress Treatment ... MPOX #Diagnosis #Management
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