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diagnosis hepatology rheumatology workup arthritis associations autoantibodies biliary causes cholangitis dic differential disseminated interpretation intravascular laboratory lfts management primary rheumatoid
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
(PBC) - Summary ... PBC Epidemiology ... but elevated as disease ... pregnancy, Cardiac diseases ... , IgG4 related disease
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... Anti-CCP, Rheumatoid ... (PBC) Anticentromere ... (TTG) - Celiac disease ... #antibodies
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... disease: > 2 ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Diseases • Septic ... Complete blood count (CBC ... exclude inflammatory disease ... connective-tissue disease ... #Disease #Rheumatoid
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... DIC • Severe Liver ... Disease: - Impaired ... HIT: Heparin-PF4 antibodies ... hydration • RBC
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