15 results
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
but elevated as disease ... PBC Diagnosis ... pregnancy, Cardiac diseases ... , IgG4 related disease ... #diagnosis #workup
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... Sickle Cell RBC
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
, PBC, PSC, IgG4 ... stone, Malignancy, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... diseases, Myelodysplastic ... diseases, Sideroblastic ... , Liver diseases ... coagulopathy (DIC) #RBC
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Differential Diagnosis ... Neutrophils - Low RBC ... • Pancreatic Disease ... Disease #Macrocytic ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... (PBC) Anticentromere ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... disease: > 2 ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
decreased PLT count: CBC ... disease, decrease ... anti-phospholipid antibodies ... disease), HBsAg ... /anti-HBc (rituximab
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... reported (eg AIH-PBC ... upper limit of normal ... #Management #Hepatology
Vibrio Vulnificus skin infection
Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. 
Vibrio vulnificus part of
skin infection Cirrhosis ... Hippocrates in 5 BC ... sepsis: chronic liver ... disease, iron overload ... University Infectious Diseases