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differential hepatology rheumatology algorithm arthritis autoantibodies biliary causes chemistry cholangitis coagulation dic disseminated gap globulin injury interpretation intravascular laboratory lfts
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
but elevated as disease ... PBC Diagnosis ... pregnancy, Cardiac diseases ... , IgG4 related disease ... #diagnosis #workup
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... (PBC) Anticentromere ... (TTG) - Celiac disease ... #diseases #diagnosis ... #antibodies
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
, PBC, PSC, IgG4 ... stone, Malignancy, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... disease: > 2 ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
DIC • Severe Liver ... Disease: - Impaired ... HIT: Heparin-PF4 antibodies ... hydration • RBC ... #Coagulation #diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... Complete blood count (CBC ... connective-tissue disease ... #Rheumatic #Disease
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... plasmacytoma • Castleman disease ... disease: Cirrhosis ... , PBC, PSC, Viral
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