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algorithm classification anemia approach causes joint msk pain antibodies antinuclear autoimmune bandemia biliary calculation cholangitis disorders erythematosus gap globulin hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
(PBC) - Summary ... Pathophysiology ... patients • +ANA ... bile ducts Differential ... #diagnosis #workup
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
12-13 g/dL, • ANC ... /uL Initial Workup ... : CBC with diff, ... LDH, ESR, CRP, iron ... #hematology #workup
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... Anemia of Chronic Disease ... Thalassemia • RBC ... Disorder • RBC ... #Causes #Hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... Patterns and Associated ... Primary Biliary Cirrhosis ... #patterns #rheumatology ... #diagnosis #differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... deficiencies: Iron ... Chronic kidney disease ... anemia, Intrinsic RBC ... Production #Index #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... function test, ANA ... ), HBsAg/anti-HBc ... #Workup #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
• WBC <2k: Noninflammatory ... lower limbs) • WBC ... presentation with lower WBC ... Joint #Pain #MSK #rheumatology ... diagnosis #arthritis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
• Autoimmune diseases ... Even with normal WBC ... 21% had normal WBC ... #WBC #CBC #hematology ... #pathophysiology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Complete blood count (CBC ... iron saturation ... #laboratory #workup ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... WBC >2000 in synovial ... • Is there a pattern ... #Diagnosis #MSK ... #rheumatology #
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