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differential rheumatology symptoms algorithm erythematosus management oncology sle systemic fever hemolytic activation agglutinin alopecia arthritis autoantibodies behcet bleeding bruising causes
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #differential #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
, Vasculitis, Purpura ... Demyelinating syndromes ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis
Fever and Rash - Differential Diagnosis Framework • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... gonorrhea, Rickettsial diseases ... , Vasculitis SCVMC ... #dermatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... Kasabach-Merritt syndrome ... #hematology #rheumatology ... #nonpalpable #dermatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... Differential Diagnosis ... • Goodpasture syndrome ... Polyangiitis #GPA #dermatology ... #rash #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... ANCA-associated vasculitis ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Hemolytic anemia ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
mucositis - Rash ... well as inner ear ... such as systemic lupus ... purpura: strong sign ... #rheumatology #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... usually IgG) (e.g. lupus ... #hematology #anemia
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