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differential rheumatology algorithm causes oncology systemic erythematosus sle alopecia blood clinical generalized hairloss leukemia photo product pruritus reactions secondary signs
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #differential #diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... pain (20%) Renal disease ... ) Blood (75%): Anemia
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... Differential Diagnosis ... • Goodpasture syndrome ... Polyangiitis #GPA #dermatology ... #rash #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... Seizures • Strokes Skin ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... usually IgG) (e.g. lupus ... #hematology #anemia
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Central Distribution, Febrile / Ill: - Viral Exanthem - Lyme Disease (erythema migrans) Central Distribution,
Exanthem - Lyme Disease ... Stevens-Johnson Syndrome ... Macules #Papules #Rash ... #Algorithm #Diagnosis ... #Dermatology #Skin
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... Petechial or purpuric rash ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
redness of the skin ... syndrome (SSS) ... includes Kawasaki disease ... erythematous rash ... #Diagnosis #Dermatology
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