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hemolytic autoimmune differential disease symptoms anorexianervosa antiglobulin behcet causes complications direct extravascular intravascular management monoclonal oncology paraproteinemias psychiatry rheumatology syndrome
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Anemia (AIHA) - ... Agglutinin Disease ... (7-8%) DAT-negative ... #Anemia #AIHA # ... #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... - Warm vs Cold ... #Anemia #Pathophysiology ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Diagnosis: • hemolytic ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Negative Hemolysis ... ), C3d ( - ) WAIHA ... , C3d ( +/- ) Cold ... agglutinin disease ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... )"Cold" (usually ... agglutin disease ... #hematology #anemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
matter, spinal cord ... Giant retinal tears ... monoclonal TNF-aIpha ... #management #signs ... #symptoms #rheumatology
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
and memory loss HEMATOLOGIC ... lymphocytosis, mild anemia ... Hypothermia and Cold ... Complications #pathophysiology ... #diagnosis #signs
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