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Focused evaluation algorithm for acute liver injury

#Liver #Injury #Acute #Evaluation #Algorithm #Diagnosis #Hepatology
algorithm for acute ... liver injury ... #Liver #Injury # ... Acute #Evaluation ... Algorithm #Diagnosis #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Injury (DILI) ... #Failure #Cirrhosis ... #Hepatology #gastroenterology
Table of Causes of Acute Liver Injury
#Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Table of Causes of Acute ... Liver Injury #Diagnosis ... #Hepatology #Acute ... #Liver #Injury
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... • NAFLD • Cirrhosis ... Hepatopathy • Acute ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe Acute ... Liver Injury ... - Drug-Induced liver ... injury - Viral ... #Differential #Hepatology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
Management of Cirrhosis ... ascites removed • Acute ... kidney injury ( ... Indications #Management #Cirrhosis ... #treatment #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... CMV), Alcoholic cirrhosis ... #Injury #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Mixed - Check Acute ... injury < 26 weeks ... hepatitis: < 1 • Cirrhosis ... : > 1 • Acute ... #differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Autoimmune hepatitis, Acute ... #Injury #Differential ... #algorithm #hepatology