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diagnosis hematology treatment blood hemophagocytic lymphohistiocytosis product reactions anemia aplastic classification disorders hodgkins lymphoma lymphoproliferative mds myelodysplastic post ptld summary
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... Drugs, Unknown cause ... 100 mg/m2) : in case ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... acute leukemia Management ... #treatment #hematology ... #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's lymphoma (HL ... of about three cases ... Lymphoma (90-95% of cases ... classification #hematology ... #oncology #management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Treatment Primary HLH ... steroids • In mild cases ... Options for severe cases ... #Treatment #management ... #hematology
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
haploidentical>unrelated>HLA ... to 50% of PTLD cases ... Lymphoproliferative #Disorders #oncology ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... donors (due to anti-HLA ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... donors (due to anti-HLA ... Transfusions #diagnosis #management ... #hematology #reactions
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