13 results
Approach to Gout
Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals
Treatment:
 • Weight loss, diet, d/c culprit
1) 2+ flares/year ... gout #diagnosis #management ... treatment #ULT #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Features: alveolitis, ear ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Treatment of giant cell arteritis (GCA)

1st Line Strategy - GC 0.7 mg/kg/day, except for:
 • Aortitis
or SC for > 1 year ... weekly SC for > 1 year ... GCA #Treatment #Management ... #Indications #rheumatology
Susac Syndrome - Clinical Triad
 - Central nervous system dysfunction
 - Branch retinal artery occlusion
 -
disease flares - 2-year ... Triad #Diagnosis #Management ... #Rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
in literature (NEJM ... cases (Cornelia NEJM ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Nicolas Taar ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Giant retinal tears ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
Diagnosis and Management ... 2 attacks in a year ... Gout #diagnosis #management ... #treatment #rheumatology
Gout - Management
Acute Gout Flare
 1) colchicine, NSAIDs, glucocorticoids
 2) Anakinra (IL-1 inhibitor)
When to Start Urate
Gout - Management ... 2+ gout flares/year ... MithuRheum #Gout #Management ... #treatment #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Symptomatic: artificial tears ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management