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hepatology differential injury aflp lfts obstetrics pregnancy transaminitis causes disease hellp management table aclf arthritis autoimmune chemistry chronic cirrhosis coagulation
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular ... • Iatrogenic: DILI ... extrahepatic source - Tests ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Diagnosis Hepatocellular ... , Acute biliary ... #Differential #Diagnosis ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... Chronic viral hepatitis ... #chemistry #diagnosis ... #differential #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... test abnormalities ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs #hepatitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... 10x ULN), ↑Tbili/Dbili ... : Viral Hepatitis ... #Pregnancy #hepatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
) • Advanced Liver ... Alcohol, Viral hepatitis ... catastrophes, Acute ... Summary #table #comparison ... #diagnosis #hematology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... Returning Traveler’ algorithm ... Test for the respective ... values supporting hematologic ... #diagnosis
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