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sle erythematosus abnormal antinuclear causes coagulation management patterns prolonged pt activation autoantibodies classification comparison macrophage mas medications mimickers pharmacology risk
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... disease (MCTD), Drug-induced ... #Antinuclear #Antibodies ... #rheumatology #diagnosis ... #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... disease (MCTD), Drug-induced ... #rheumatology #diagnosis ... #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... and the aPTT are ... antiphospholipid antibodies ... associated with systemic ... hematology #coagulation
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... Diagnosis and Lupus ... #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Drug Induced Systemic ... for 1 year of treatment ... Lupusreference #DrugInduced ... #medications #drugs ... #diagnosis #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
antiphospholipid antibodies ... associated with systemic ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... months to years) Systemic ... Lupusreference #druginduced ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... /or medications ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis: Systemic ... lupus erythematosus ... LFT • ESR • ANA ... ) pattern: antibodies ... #diagnosis #rheumatology
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