Medication Differential NMS dermatology syndrome anemia clinical rheumatology hemolytic hemolysis workup diagnosis mcv testing aplastic disease cold agglutinin pancytopenia

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

for Hemolysis - ... Intravascular Hemolysis ... Microangiopathic hemolytic ... agglutin disease ... #diagnosis #hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Agglutinin Syndrome ... Diagnosis: • hemolytic ... • Compensated hemolysis ... #hemolytic #anemia ... #hematology #diagnosis

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... agglutinins disease ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... #workup #hematology

Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
1. Autoimmune Mediated Pancytopenia
2. Splenic Sequestration
Peripheral Destruction

Pancytopenia - Workup ... Anemia • Hypoplastic ... Metastatic Disease ... #Workup #Differential ... #Hematology

Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years

What?
• Aplastic anemia

Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... - Antithyroid medications ... #hematology #diagnosis

Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?

→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

Diagnosis and Workup ... family history - Medications ... testing - Lab ... anemia (vegan, ... #Workup #hematology

Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone

• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology

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