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hematology oncology anemia aplastic causes chronic cll evaluation gap globulin hemolytic inherited lymphocytic management mds myelodysplasia myelodysplastic platelet platelets protein
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential # ... Algorithm #Thrombocytopenia
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... Diagnosis #Algorithm ... #Causes #Hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... Grey Platelet Syndrome ... #comparison #table ... #differential # ... diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Diagnosis Algorithm ... Schistocytes, thrombocytopenia ... #Diagnosis #Algorithm ... #workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• M > F • Affects ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... #diagnosis #workup ... #oncology #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... for workup, including ... #Diagnosis #Algorithm ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... - Antithyroid medications ... virus (EBV) • Leukemia ... Anemia #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease • Neutropenia ... Workup: • Complete ... blood count with differential ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
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