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diagnosis causes hematology algorithm systemic dermatology generalized oncology thrombocytosis atlas diseases erythematosus ild interstitial key leukemia lung lupus mcv mds
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... #secondary
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic kidney ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... morphologic #mcv #differential ... diagnosis #causes #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Liver diseases, Myelodysplastic ... syndrome, Increased ... PD deficiency, Pulmonary ... key #diagnosis #differential ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... Marrow Failure • Chronic ... blood count with differential ... #hematology #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Myelodisplastic syndrome ... #primary #secondary
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Discoloration • Medications ... discoloration) • Chronic ... • Nephrotic syndrome ... #dermatology #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... • Infections: Chronic
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Myelodisplastic syndrome ... #secondary #systemic
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
pneumonitis • Medication-induced ... Methotrexate ILD Secondary ... Churg Strauss syndrome ... pneumonia: Acute, Chronic ... ILD #diagnosis #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
sweats, bleeding • Pruritis ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary
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